Publications

Plasma N  -Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study Clemens Wittenbecher, Tamara Štambuk, Olga Kuxhaus, Najda Rudman, Frano Vučković, Jerko Štambuk, Catarina Schiborn, Dario Rahelić, Stefan Dietrich, Olga Gornik, Markus Perola, Heiner Boeing, Matthias B. Schulze, Gordan Lauc Diabetes Care 10.2337/dc19-1507
Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection Tanya M. Monaghan, Maja Pučić-Baković, Frano Vučković, Christine Lee, Dina Kao, Iwona Wójcik, Filip Kliček, Christos Polytarchou, Brandi Roach, Tom Louie, Peter Kim, Brandi Roach, Christos Polytarchou, Marcin Frankowski, Gordan Lauc Gastroenterology 10.1053/j.gastro.2019.08.034
Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang Biomarkers in Medicine 10.2217/bmm-2019-0005
Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes Najda Rudman, Olga Gornik, Gordan Lauc FEBS Letters 10.1002/1873-3468.13495
Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang OMICS: A Journal of Integrative Biology 10.1089/omi.2019.0052
A Matrix-Assisted Laser Desorption/Ionization—Mass Spectrometry Assay for the Relative Quantitation of Antennary Fucosylated N-Glycans in Human Plasma Osmond D. Rebello, Simone Nicolardi, Guinevere S. M. Lageveen-Kammeijer, Jan Nouta, Richard A. Gardner, Wilma E. Mesker, Rob A. E. M. Tollenaar, Daniel I. R. Spencer, Manfred Wuhrer, David Falck Frontiers in Chemistry 10.3389/fchem.2020.00138
Decreased Immunoglobulin G Core Fucosylation, A Player in Antibody-dependent Cell-mediated Cytotoxicity, is Associated with Autoimmune Thyroid Diseases Tiphaine C. Martin, Mirna Šimurina, Marta Ząbczyńska, Marina Martinic Kavur, Magdalena Rydlewska, Marija Pezer, Kamila Kozłowska, Andrea Burri, Marija Vilaj, Renata Turek-Jabrocka, Milena Krnjajić-Tadijanović, Małgorzata Trofimiuk-Müldner, Ivo Ugrina, Anna Lityńska, Alicja Hubalewska-Dydejczyk, Irena Trbojevic-Akmacic, Ee Mun Lim, John P. Walsh, Ewa Pocheć, Tim D. Spector, Scott G. Wilson, Gordan Lauc Molecular & Cellular Proteomics 10.1074/mcp.ra119.001860
Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci Justina Briliūtė, Paulina A. Urbanowicz, Ana S. Luis, Arnaud Baslé, Neil Paterson, Osmond Rebello, Jenifer Hendel, Didier A. Ndeh, Elisabeth C. Lowe, Eric C. Martens, Daniel I. R. Spencer, David N. Bolam, Lucy I. Crouch Nature Microbiology doi: 10.1038/s41564-019-0466-x
Fucosidases from the human gut symbiont Ruminococcus gnavus Haiyang Wu, Osmond Rebello, Emmanuelle H. Crost, C. David Owen, Samuel Walpole, Chloe Bennati-Granier, Didier Ndeh, Serena Monaco, Thomas Hicks, Anna Colvile, Paulina A. Urbanowicz, Martin A. Walsh, Jesus Angulo, Daniel I. R. Spencer, Nathalie Juge Cellular and Molecular Life Sciences 10.1007/s00018-020-03514-x
MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation Thomas Sénard, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega Frontiers in Immunology 10.3389/fimmu.2020.02049
Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of individual healthy donors Iwona Wojcik, Thomas Sénard, Erik de Graaf, George Janssen, Arnoud de Ru, Yassene Mohammed, Peter A. van Veelen, Gestur Vidarsson, Manfred Wuhrer, David Falck Analytical Chemistry 10.1021/acs.analchem.0c02342
Metformin and statin use associate with plasma protein
N -glycosylation in people with type 2 diabetes		 Sunny S Singh, Annemieke Naber, Viktoria Dotz, Emma Schoep, Elham Memarian, Roderick C Slieker, Petra J M Elders, Gerda Vreeker, Simone Nicolardi, Manfred Wuhrer, Eric J G Sijbrands, Aloysius G Lieverse, Leen M ‘t Hart, Mandy van Hoek BMJ Open Diabetes Research & Care 10.1136/bmjdrc-2020-001230
Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis – mass spectrometry Alan B. Moran, Elena Domínguez-Vega, Jan Nouta, Tamas Pongracz, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer Journal of Proteomics 10.1016/j.jprot.2021.104148
N-glycome of the Lysosomal Glycocalyx is Altered in Niemann-Pick Type C Disease (NPC) Model Cells Marko Kosicek, Ivan Gudelj, Anita Horvatic, Tanja Jovic, Frano Vuckovic, Gordan Lauc, Silva Hecimovic Molecular & Cellular Proteomics 10.1074/mcp.ra117.000129
Interlaboratory evaluation of plasma N-glycan antennary fucosylation as a clinical biomarker for HNF1A-MODY using liquid chromatography methods Daniel Demus; Bas C. Jansen; Richard A. Gardner; Paulina A. Urbanowicz; Haiyang Wu; Tamara Štambuk; Agata Juszczak; Edita Pape Medvidović; Nathalie Juge; Olga Gornik; Katharine R. Owen; Daniel I. R. Spencer Glycoconjugate Journal 10.1007/s10719-021-09992-w
Large-Scale Analysis of Apolipoprotein CIII Glycosylation by Ultrahigh Resolution Mass Spectrometry. Daniel Demus; Daniel Demus; Annemieke Naber; Viktoria Dotz; Bas C. Jansen; Bas C. Jansen; Marco R. Bladergroen; Jan Nouta; Eric J. G. Sijbrands; Mandy Van Hoek; Simone Nicolardi; Manfred Wuhrer Frontiers in Chemistry, Vol 9 (2021) 10.3389/fchem.2021.678883
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity. Mads Delbo Larsen; Erik L. de Graaf; Myrthe E. Sonneveld; H. Rosina Plomp; Jan Nouta; Willianne Hoepel; Hung-Jen Chen; Federica Linty; Remco Visser; Maximilian Brinkhaus; Tonci Sustic; Steven W. de Taeye; Arthur E. H. Bentlage; Suvi Toivonen; Carolien A. M. Koeleman; Susanna Sainio; Neeltje A. Kootstra; Philip J. M. Brouwer; Chiara Elisabeth Geyer; Ninotska I. L. Derksen; Gertjan Wolbink; Menno P.J. de Winther; Rogier W. Sanders; Rogier W. Sanders; Marit J. van Gils; Sanne de Bruin; Alexander P.J. Vlaar; Amsterdam Umc Covid; Theo Rispens; Jeroen den Dunnen; Hans L. Zaaijer; Manfred Wuhrer; C. Ellen van der Schoot; Gestur Vidarsson Science 10.1126/science.abc8378
A functional spleen contributes to afucosylated IgG in humans Iwona Wojcik; David E. Schmidt; Lisa A. de Neef; Minke A. E. Rab; Bob Meek; Okke de Weerdt; Manfred Wuhrer; C. Ellen van der Schoot; Jaap J. Zwaginga; Masja de Haas; David Falck; Gestur Vidarsson Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) 10.1038/s41598-021-03196-w
Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans Russell, Alyce C.; Kepka, Agnieszka; Trbojević-Akmačić, Irena; Ugrina, Ivo; Song, Manshu; Hui, Jennie; Hunter, Michael; Laws, Simon M.; Lauc, Gordan; Wang, Wei Immunobiology 10.1016/j.imbio.2018.10.002
Why Not Use the Immunoglobulin G N-Glycans as Predictor Variables in Disease Biomarker–Phenotype Association Studies? A Multivariate Analysis Alyce C. Russell, Agnieszka Kepka, Irena Trbojević-Akmačić, Ivo Ugrina, Manshu Song, Jennie Hui, Michael Hunter, Simon M. Laws, Gordan Lauc, and Wei Wang OMICS: A Journal of Integrative Biology 10.1089/omi.2019.0155
The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations JN Liu, M Dolikun, J Štambuk, I Trbojević-Akmačić, J Zhang, H Wang, DQ Zheng, XY Zhang, HL Peng, ZY Zhao, D Liu, Y Sun, Q Sun, QH Li, JX Zhang, M Sun, WJ Cao, A Momčilović, G. Razdorov, LJ Wu, A Russell, YX Wang, MS Song, G Lauc & W Wang JOURNAL OF HUMAN HYPERTENSION 10.1038/s41371-018-0071-0
Profiling and genetic control of the murine immunoglobulin G glycome Jasminka Krištić, Olga O. Zaytseva, Ramesh Ram, Quang Nguyen, Mislav Novokmet, Frano Vučković, Marija Vilaj, Irena Trbojević-Akmačić, Marija Pezer, Kathleen M. Davern, Grant Morahan & Gordan Lauc NATURE CHEMICAL BIOLOGY 10.1038/s41589-018-0034-3
Immunoglobulin G N-Glycans as Potential Postgenomic Biomarkers for Hypertension in the Kazakh Population Qing Gao, Mamatyusupu Dolikun, Jerko Štambuk, Hao Wang, Feifei Zhao, Nizam Yiliham, Youxin Wang, Irena Trbojević-Akmačić, Jie Zhang, Honghong Fang, Yang Sun, Hongli Peng, Zhongyao Zhao, Di Liu, Jiaonan Liu, Qihuan Li, Qi Sun, Lijuan Wu, Gordan Lauc, Wei Wang, and Manshu Song OMICS: A Journal of Integrative Biology 10.1089/omi.2017.0044
Glycosylation of IgG Associates with Hypertension and Type 2 Diabetes Mellitus Comorbidity in the Chinese Muslim Ethnic Minorities and the Han Chinese Xiaoni Meng, Manshu Song, Marija Vilaj, Jerko Štambuk, Mamatyusupu Dolikun, Jie Zhang, Di Liu, Hao Wang, Xiaoyu Zhang, Jinxia Zhang, Weijie Cao, Ana Momčilović, Irena Trbojević-Akmačić, Xingang Li, Deqiang Zheng, Lijuan Wu, Xiuhua Guo, Youxin Wang, Gordan Lauc, and Wei Wang JOURNAL OF PERSONALIZED MEDICINE 10.3390/jpm11070614
Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases Mirna Šimurina, Noortje de Haan, Frano Vučković, Nicholas A Kennedy, Jerko Štambuk  David Falck, Irena Trbojević-Akmačić, Florent Clerc, Genadij Razdorov, Anna Khon, Anna Latiano, Renata D’Incà, Silvio Danese, Stephan Targan, Carol Landers, Marla Dubinsky, Inflammatory Bowel Disease Biomarkers Consortium; Dermot P B McGovern, Vito Annese, Manfred Wuhrer, Gordan Lauc GASTROENTEROLOGY 10.1053/j.gastro.2018.01.002
The sweet spot for biologics: recent advances in characterization of biotherapeutic glycoproteins O’Flaherty, R (O’Flaherty, Roisin) [1]; Trbojevic-Akmacic, I (Trbojevic-Akmacic, Irena) [2]; Greville, G (Greville, Gordon) [1]; Rudd, PM (Rudd, Pauline M.) [1]; Lauc, G (Lauc, Gordan) [2], [3] EXPERT REVIEW OF PROTEOMICS 10.1080/14789450.2018.1404907
Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes Elham Memarian, Leen M ‘t Hart, Roderick C Slieker, Roosmarijn F L Lemmers, Amber A van der Heijden, Femke Rutters, Giel Nijpels, Emma Schoep, Aloysius G Lieverse, Eric J G Sijbrands, Manfred Wuhrer, Mandy van Hoek, Viktoria Dotz BMJ OPEN DIABETES RESEARCH & CARE 10.1136/bmjdrc-2021-002345
A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG Osmond D. Rebello, Richard A. Gardner, Paulina A. Urbanowicz, David N. Bolam, Lucy I. Crouch, David Falck & Daniel I. R. Spencer Glycoconjugate Journal 10.1007/s10719-020-09953-9