GlySign aims at the the advancement of medical glycomics, currently hampered by three main factors:
Glycoproteins display glycan microheterogeneity, the analysis of which has been successfully tackled in a research setting, but remains a challenge in typical clinical chemistry labs. GlySign aims at the development of facile and robust procedures for high‐resolution glycomics analysis in a clinical lab setting.
Biomarker translation is too rarely attempted: biomarkers discovered in fundamental research are rarely translated into medical practice and meaningful health outcomes due to a lack of quality in biomarker validation, among other reasons. This project aims to bring clinically validated glycomics biomarkers into the clinic, thereby demonstrating the additional value of glycomics for PM.
Glycomics is a technically difficult, highly specialised field and practitioners must be skilled to a high level in a wide range of analytical technologies. Also, large, complex multi‐dimensional datasets impede interpretation. GlySign aims to train skilled glycomics specialists.