GlySign, as a European Industrial Doctorate (EID), exploits the key translational synergies between excellent academic and non‐academic partners to the fullest extent.

We offer 6 PhD positions, in the fields of glycoproteomics, (analytical) glycobiology andclinical mass spectrometry. The six early Stage Researchers (ESRs) will be trained in advanced glycomics technologies arising from the EU-FP7 HighGlycan programme, as well as other orthogonal glycoanalytical methods developed by consortium members. These will be applied to glycomics studies of blood samples from patients and healthy controls of four model deseases: diabetes, prostate cancer, rheumatoid arthritis and fetal and neonatal alloimmune thrombocytopenia (FNAIT). The specific purpose is the development of skills for translating glycomics methods into practical tools for PM (personalized medicine).


What we offer

Each ESR will be employed by one of the three beneficiaries, based in the Netherlands, in Croatia and in England respectively. The candidates will be supported by H2020-MSCA-ITN funding for a maximum of 36 months. When more than 36 months are required for completion of the PhD program, the hosting institute might arrange funding, which may differ from that of the H2020-MSCA-ITN. Salary includes a living allowance, adjusted for location, and a mobility allowance. An additional family allowance may be payable depending on circumstances.

The successful candidates will benefit from a wide-ranging training programme: they will receive training in MS (mass spectrometry) for proteomics and glycoproteomics; clinical data management and analysis; statistical data analysis; data analysis automation; strategies for transfer of technology into clinical application; working under GMP; scientific writing as well as non-academic reporting; teaching and mentoring.

Training by doing RESEARCH: Each of the ESRs will spend at least 50% of their research time at one (or more) industrial partner, while working towards their PhD at the LUMC. This will ensure a uniform academic training as well as a high level of intersectorial exposure.

The ESRs will participate in events and workshops as well as local courses and (inter)national conferences. There will be ample opportunity to meet other ESRs involved in the programme, and to travel to other European partners in the network.

How to apply

GlySign welcomes applications from all suitably qualified candidates, irrespective of gender, disability, marital or parental status, racial, ethnic or social origin, colour, religion, belief or sexual orientation.

The candidates should hold a master degree in life sciences (e.g. biochemistry) or analytical chemistry. A good level of English (spoken and written) is mandatory. The candidates should be good communicators with the ability to develop work relationships and have strong analytical skills particularly with an attention to detail. They should be an independent thinker with a proven ability to project manage their work and meet deadlines. They should be able to work efficiently as part of a team and to build upon our collaborations. For specific requirements, please refer to the individual job descriptions.

The selection for each post will include:

► pre-selection (based on CV and motivation letter) by our international selection committee (composed of experts from different fields and from both private and public sector)

► web-based video interview 

► In loco interview

Eligibility Criteria

Given that the positions are funded by the European Commission on a H2020-MSCA-ITN, eligibility restrictions apply:

  1. EXPERIENCE: Early-Stage Researchers (ESRs) shall, at the time of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. For the purpose of determining eligibility, full-time equivalent research experience is measured from the date when a researcher obtained the degree which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher is recruited or seconded, irrespective of whether or not a doctorate is or was ever envisaged. Full-time equivalent research experience may include periods of research such as work on certain MSc or MPhil degrees, time spent as a research assistant or laboratory technician in a research environment or time spent in an industrial research and development environment. This list is not exhaustive and should act as a general indication only. The four year period (or 48 months) is an aggregated period since the award of the degree that would allow you to embark on doctoral studies and is not a simple “four year” cut off.
  2. MOBILITY RULE: at the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date. Compulsory national service and/or short stays such as holidays are not taken into account.

PhD position in quantitative glycoproteomics
<h5><strong>PhD position in quantitative glycoproteomics</strong></h5>
Absolute LC-MS based quantitation of serum IgG Fc N-glycosylation for patient stratification in chronic inflammatory diseases

Job description (pdf)

Online application form  

PhD position in
glycobiology
<h5><strong>PhD position in<br> glycobiology</strong></h5>
MS analysis of the glycosylation of total and of antigen-specific serum IgG for disease severity estimation in fetal/neonatal alloimmune thrombocytopenia (FNAIT) patients

Job description (pdf)

Online application form  

PhD position in
glycobiology
<h5><strong>PhD position in <br>glycobiology</h5></strong>
Plate-based enzyme assays
for IgG Fc analysis for patient stratification
in auto-and alloimmune diseases

Job description (pdf)

Online application form  

PhD position in clinical mass spectrometry for glycoprotein analysis
<h5><strong>PhD position in clinical mass spectrometry for glycoprotein analysis</h5></strong>
Assessing prostate-specific antigen (PSA) for prostate cancer (PCa) detection combined with glycoform quantitation aiming at patient stratification

Job description (pdf)

Online application form  

PhD position in
glycobiology
<h5><strong>PhD position in<br> glycobiology</h5></strong>
Quantification of serum protein glycosylation for patient stratification in early onset diabetes

Job description (pdf)

Online application form  

PhD position in
analytical glycobiology
<h5><strong>PhD position in<br> analytical glycobiology</h5></strong>
Multi-platform based quantification approach to patient sample stratification for an early onset diabetes sample cohort

Job description (pdf)

Online application form